• We found that the postnatal absence of norepinephrine yields

  2020-08-05

  

  We found that the postnatal absence of norepinephrine yields differing effects depending on noradrenergic receptor type and gsk products receptor region. The density of α1-AR, indicated by [3H]prazosin binding was similar between Dbh+/− and Dbh−/− mice except for a significant increase in hippocamp

• In the present study we described the

  2020-08-05

  

  In the present study, we described the cloning and sequencing of a G3DH gene from Rhizobium sp. S10 and its co-expression in E. coli. The recombinant enzyme, identified as rG3DH, was consequently purified, characterized and utilized in d-gulose production. Materials and methods Results Disc

• The genomic DNA sequences of CXCL and CXCRs were

  2020-08-05

  

  The genomic DNA sequences of CXCL8 and CXCRs were retrieved from the fugu genome database v4.0. The intron–exon boundaries were identified with the corresponding cDNA sequences. This comparison revealed that the fugu gene is about 1.13kb long and contains four exons separated by three introns (top p

• br Significance Systems and synthetic biology have become ke

  2020-08-04

  

  Significance Systems and synthetic biology have become key research areas. What is missing is an experimental system in which the knowledge gained from molecular analyses could be reproduced in an artificial setting that is void of the risk of natural contamination. We work at setting up a self-r

• Noteworthy glycation resulted in significant change of

  2020-08-04

  

  Noteworthy, glycation resulted in significant change of α-synuclein region involved in the binding. Thus, native α-synuclein without modifications interacted with GAPDH generally via C-terminal region (Fig. 3B, top panel) enriched with negatively charged residues (see the band below the bar chart, n

• Thirty eight papers are reported in PubMed upon the

  2020-08-04

  

  Thirty-eight papers are reported in PubMed upon the keyword search “DDR1 AND kidney”. Careful examination of those papers shows that only 31 are related to DDR1\'s role in glomerulosclerosis and renal fibrosis, 24 of those being research and the rest review articles. Since the original paper describ

• Calmodulin CaM is a multifunctional calcium

  2020-08-04

  

  Calmodulin (CaM) is a multifunctional calcium transducer [8]. It functions as a central regulator of cellular metabolism in response to changes in cellular calcium levels by interacting with various targets [9]. Numerous studies have been devoted to the understanding CaM mechanism of action. Early m

• br GPCRs are flexible seven

  2020-08-04

  

  GPCRs are flexible seven-transmembrane (7TM) proteins that can isomerize between inactive and active conformations. Binding of the endogenous agonist to its orthosteric binding site on the GPCR promotes transition of the receptor from an inactive to an active state that can interact with intracell

• br The glycyl radical enzymes substrates for the

  2020-08-04

  

  The glycyl radical enzymes: substrates for the GRE–AEs The GRE–AEs are a subclass of radical SAM enzymes which, after the production of the dAdo·, abstract a hydrogen atom from the alpha carbon of a highly conserved glycine residue in the enzymes known as glycyl radical enzymes (GREs). The result

• Identification of the A S DNA recognition sequence and

  2020-08-04

  

  Identification of the A1S_0222 DNA recognition sequence and methyltransferase activity. According to REBASE, a database in which information about restriction enzymes, DNA methyltransferases, recognition and cleavage sites, published and unpublished references are collected [50,51], the A. baumannii

• Vinorelbine ditartrate Although the ferromagnetic particles

  2020-08-04

  

  Although the ferromagnetic particles and T4 Vinorelbine ditartrate on the particles were heated by the ac magnetic field, the average temperature of the reaction solution as a whole was kept suitably low for the annealing of DNA ends (16°C). Indeed, no appreciable increase in the temperature of the

• br Experimental procedures br Introduction Protein kinases r

  2020-08-03

  

  Experimental procedures Introduction Protein kinases represent one of the largest enzyme Cl-Amidine trifluoroacetate salt in the human genome and act as signaling mediators in a variety of cellular processes (Manning et al., 2002). Because many diseases are associated with aberrant protein ki

• There are some limitations to take into

  2020-08-03

  

  There are some limitations to take into account when interpreting these results. Firstly, direct causation cannot be established in this cross-sectional study, and it may be the downstream effects of TNFα, such as increased ONO-8711 production, which are more proximally related to cognitive dysfunc

• br Materials and methods br Results

  2020-08-03

  

  Materials and methods Results Discussion These findings suggest that, along with other factors that dysregulate fatty 2-D08 and lipid metabolism in HIV-infected people [29], several of the currently prescribed ritonavir-boosted HIV-PIs directly impair the ability of skeletal muscle cells to

• br Materials and Methods br Results br Discussion Mitochondr

  2020-08-03

  

  Materials and Methods Results Discussion Mitochondrion not only generates energy but also produces ROS under physiological conditions. However, overnutrition causes mitochondrial congestion and elicits excessive ROS generation, leading to insulin resistance (Muoio, 2014, Houstis et al., 200

15997 records 794/1067 page Previous Next First page 上5页 791792793794795 下5页 Last page