• extra Although we observed increases in AR

  2021-03-02

  

  Although we observed increases in α1-AR mediated cAMP production separately in the nucleus and cytoplasm, compartment specificity was observed for PKA activation. GPCRs and their effector proteins are commonly found in multiprotein signalosomes with A-kinase anchoring proteins (AKAPs) serving as sca

• In this study we further investigate how STAT integrate

  2021-03-02

  

  In this study, we further investigate how STAT3 integrate to the core regulatory circuit in ESC pluripotency and differentiation, and identify Mettl8 as a downstream target of STAT3 in mESCs. We discover the role of METTL8 as a negative regulator of JNK signaling in stem cells. Our results provide i

• love herself To further investigate mechanisms of rXCI we ge

  2021-03-02

  

  To further investigate mechanisms of rXCI, we generated female ESCs with a homozygous RlimKO. We found that these love herself undergo XCI in vivo but that XCI in vitro is strongly influenced by culture conditions, including both method of differentiation and O2 levels. Our results demonstrate Rlim-

• br Disclosure statement br Acknowledgements This research

  2021-03-02

  

  Disclosure statement Acknowledgements This research was supported by grants from the National Institutes of Health, NS046400 and AG022971 (SD), and a fellowship from the Korea Research Foundation, KRF-2007-357-E00016 (YTK). The authors thank Dr. Barbara Crain for assistance with the immunologi

• Our previous work has demonstrated

  2021-03-02

  

  Our previous work has demonstrated that two glutamate residues (Glu-305 and Glu-331 in murine and human TPP II) in the active site are important for exopeptidase activity in mTPP II [17]. At least one of these, Glu-331, seems to form a salt bridge to the N-terminal amino group of the substrate, posi

• Methods br Results br Discussion

  2021-03-02

  

  Methods Results Discussion It is well established that CRSwNP is characterized by TH2 inflammation and eosinophilia.22, 27 Yet it is becoming increasingly apparent that B cells might play an important role in the inflammatory response within the sinus tissue of patients with CRSwNP.8, 9 The l

• br Four active site residues of

  2021-03-02

  

  Four active site residues of Δ1-KSTD1 are fully conserved in Δ1-KSTDs from different species (Supplementary Figure S2). These residues are Tyr-119, Tyr-487, and Gly-491 from the FAD-binding domain and Tyr-318 from the catalytic domain. The structure of the Δ1-KSTD1•ADD complex revealed that the hy

• br Conflict of interest br Acknowledgments Dr Hauger

  2021-03-02

  

  Conflict of interest Acknowledgments Dr. Hauger was supported by a BLR&D Merit Review grant from the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development. Dr. Hauger also received support from the VA Center of Excellence for Stress and Mental Healt

• In the present study we did not examine

  2021-03-02

  

  In the present study, we did not examine whether the CpG site-specific COMT methylation are associated with any genetic variants in response to E2, GEN or SFN. Some studies suggest that oxidative DNA damage causes genetic variation which may induce epigenetic changes that lead to gene silencing (Kho

• Many studies have shown that curcumin delays the

  2021-03-02

  

  Many studies have shown that curcumin delays the progression of atherosclerosis in different atherosclerotic animal models [18], [19], [20], [37] and the risk of atherosclerosis in human studies [15], [38], [39]. Curcumin also has many properties that contribute to combat atherosclerosis, such as an

• Our published results also show

  2021-03-02

  

  Our published results also show that the Y2 and the Y5, but not the Y1, receptors mediate NPY-induced excitation-secretion coupling in EECs (Abdel-Samad et al., 2012). Thus, it is highly important to consider controlling ET-1 circulating level via blockade of Y2 and/or Y5 receptor activation (Abdel-

• The genetic asymmetries between parental genomes

  2021-03-02

  

  The genetic asymmetries between parental genomes are also the subject of genetic conflict theory. This concept proposes that paternally inherited imprinted genes “extract” nutrients from the mother during gestation. By contrast, maternally inherited genes counteract the effect of paternal genes (Con

• Herein we further established a dynamic DNA

  2021-03-02

  

  Herein, we further established a dynamic DNA self-assembly activated hemin-mimetic enzymes system by embedding DNA-hemin into an entropy-driven DNA-assembly for fluorescent biosensing. The entropy-driven dynamic DNA-assembly is one of the toehold-mediated isothermal strand displacement reactions, wh

• br Results and Discussion br Conclusions Understanding the c

  2021-03-01

  

  Results and Discussion Conclusions Understanding the connections between function and fitness is a primary goal of many biological disciplines including systems biology and molecular evolution. While sound approaches have been developed to understand the connections between function and fitnes

• Consistent with the known tolerance of the Suzuki Miyaura re

  2021-03-01

  

  Consistent with the known tolerance of the Suzuki–Miyaura reaction to a wide range of aryl substituents, we subsequently found that the commercially available 3-hydroxyphenylboronic Neuropeptide Y 13-36 (porcine) pinacol ester () could be coupled to , to give directly and in comparable yield. Smoo

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