• GPR also known as EBI is a G i coupled

  2021-06-09

  

  GPR183 (also known as EBI2) is a Gαi-coupled seven-transmembrane chemotactic receptor. It is highly expressed on follicular B cells, CD4+ dendritic cells (DCs), and CD4+ T cells but is downregulated on germinal center (GC) CU CPT 22 in secondary lymphoid organs and controls cell migration to achiev

• CAA is a carcinogenic metabolite of vinyl chloride

  2021-06-08

  

  CAA is a carcinogenic metabolite of vinyl chloride, forming several different DNA adducts including the cyclic Ketorolac tromethamine salt adducts 3,N4-ethenocytosine (εC), 1,N6-ethenoadenine (εA), N2,3-ethenoguanine (εG), and 1,N2-ethenoguanine (1,N2-εG), with the A and C cyclic adducts the most

• The binding of collagen X to

  2021-06-08

  

  The binding of collagen X to DDR2 differs from the binding of collagen X to α2β1 integrin in that the triple helical conformation is essential for DDR2 binding. We previously reported that heat denatured pepsinised collagen X supported cell adhesion via α2β1, indicating that the triple-helical confo

• br Results br Discussion MSCs derived from the bone

  2021-06-08

  

  Results Discussion MSCs derived from the bone marrow and adipose tissue have been shown to promote the growth and metastatic ability of breast cancer and other human malignancies, but the mechanisms are incompletely understood (Barcellos-Hoff et al., 2013, Cuiffo et al., 2014, Del Pozo Martin

• br Proteases with special focus on cysteine proteases br

  2021-06-08

  

  Proteases with special focus on cysteine proteases Vaccination using cysteine proteases as antigens with special emphasis on DNA-vaccines Concluding remarks In spite of the great potential of DNA vaccines, the technology has not been as revolutionary as expected in higher mammals. In fish,

• Based on our studies presented above atipamezole can

  2021-06-08

  

  Based on our studies presented above, atipamezole can be used as a new in vitro and in vivo tool mecamylamine receptor as a pan-CYP inhibitor for CYP mediated metabolism study. It carries many unique characteristics compared to ABT which is currently being widely used for this purpose. These new ch

• leukotriene receptor antagonist Testosterone is inactivated

  2021-06-08

  

  Testosterone is inactivated through hydroxylation and conjugation pathways [3], [4]. 6β-Hydroxylation is the main pathway among testosterone hydroxylation processes in the liver microsome. Testosterone 6β-hydroxylation is mainly catalyzed by cytochrome P450 3A (CYP3A) [5], [6], which is expressed in

• br Results br Discussion Unraveling the molecular details of

  2021-06-08

  

  Results Discussion Unraveling the molecular details of nucleoporin-karyopherin interactions, which have to be strong enough to promote transport but sufficiently weak to avoid stalling of transport complexes within the pore, is key to our understanding of the mechanisms of nucleocytoplasmic tr

• After repeated intermittent exposure to a psychostimulant

  2021-06-08

  

  After repeated, intermittent exposure to a psychostimulant an augmentation of drug response to motor activity is commonly observed, a phenomenon known as behavioral sensitization (Kalivas and Stewart, 1991, Steketee and Kalivas, 2011). On the other hand, several reports have pointed out that stress

• cAMP mediated signaling pathways are important

  2021-06-08

  

  cAMP-mediated signaling pathways are important for maintaining metabolic homeostasis, and the effects of the glucagon/catecholamine–cAMP–PKA axis on energy balance have been well documented [20]. For example, cycloheximide solubility of the PKA 2β regulatory subunit (RIIβ) in mice leads to increase

• br Materials and methods br Results br Discussion Here we

  2021-06-07

  

  Materials and methods Results Discussion Here we show expression of the EP1 receptor in the hippocampus of mice and the functional influence of the EP1 receptor on kainic CC-223 sale induced seizures. Mice lacking a functional EP1 receptor gene displayed a lower tendency to enter status ep

• Interestingly anti inflammatory actions for sPLA V

  2021-06-07

  

  Interestingly, anti-inflammatory actions for sPLA2-V were also described in mice a few years ago in a model of autoimmune complex mediated arthritis [148]. A novel mechanism was delineated, whereby sPLA2-V promotes phagocytosis of immune complexes by macrophages to ameliorate inflammation in autoimm

• An important role for the precursor molecule of the

  2021-06-07

  

  An important role for the precursor molecule of the main EBI2 ligand, 25-OHC, in the inhibition of inflammation was recently shown. 25-OHC was demonstrated to inhibit inflammasome induction in mouse macrophages [28]. Inflammasome assemblies are the sites of caspase 1 activation and lead to the gener

• The human MARCH family comprises eleven members termed

  2021-06-07

  

  The human MARCH family comprises eleven members (termed MARCH-1 to 11), of which nine are transmembrane proteins. In this review, we focus on the role of the membrane-spanning MARCH proteins and how their transmembrane regions can mediate interactions with their target proteins. Therefore, the cytos

• The absence of the LIG gene in yeasts has

  2021-06-07

  

  The absence of the LIG3 gene in yeasts has prevented the use of genetically tractable lower eukaryotes, such as Saccharomyces cerevisiae and Schizosaccharomyces pombe, as models to gain insights into the cellular functions of and interplay between the DNA ligases encoded by the LIG1, LIG3 and LIG4 g

16381 records 657/1093 page Previous Next First page 上5页 656657658659660 下5页 Last page