• In conclusion our results showed that FFAR can mediate the

  2022-06-02

  

  In conclusion, our results showed that FFAR1 can mediate the effect of PIO in attenuating β-cell lipoapoptosis through anti-oxidative stress, which may be related to the activation of the PLCγ-ERK1/2-PPARγ pathway. Our study helps not only to distinguish the role played by FFAR1 in lipotoxicity, but

• br Materials and methods br Results br Discussion

  2022-06-02

  

  Materials and methods Results Discussion Cell migration not only plays major roles in physiological events, such as embryo implantation, embryogenesis, morphogenesis, neurogenesis, angiogenesis, wound healing and inflammation [[29], [30], [31]], but it is also implicated in the pathophysiol

• br Discussion The initial reduction and the

  2022-06-02

  

  Discussion The initial reduction and the subsequent increase in permeability proposes a regulatory process to control bleeding. However, following repeated injury, or during long-term presence of the inflammatory stimuli, these mechanisms may become defective and even detrimental. The expression

• Recent studies in our laboratory demonstrated that

  2022-06-02

  

  Recent studies in our laboratory demonstrated that several histamine H1 receptor antagonists induce apo A-I gene expression while histamine itself represses it [20]. In humans, there are three histamine receptor genes (H1, H2, and H3) that code for G-protein-coupled receptors (GPCR's) which bind his

• br Although there are growing bodies of research dealing

  2022-06-02

  

  Although there are growing bodies of research dealing with diverse non-imidazole based compounds, they are not free from obstacles in their development pipeline and hence the design of these compounds is complicated by various factors briefly discussed below. One of the problems in designing H3R a

• In order to estimate the

  2022-06-02

  

  In order to estimate the influence of mitochondrial hypo-polarization on generated OMP, IMP was changed from the normal value of Δψi = −140 mV (Fig. 4A, D, G) to Δψi = −100 mV (Fig. 4B, E, H), resulting in lower magnitudes of calculated OMP for hypo-polarized PNU-120596 (Fig. 4B). Similarly, a remar

• Introduction As a compound class histone deacetylase inhibit

  2022-06-02

  

  Introduction As a compound class, histone deacetylase inhibitors (HDIs) have been remarkably successful in the treatment of T-cell lymphoma [1]. Vorinostat (suberanilohydroxamic mk-801 mg or SAHA) was approved by the FDA in 2006 for the treatment of cutaneous T-cell lymphoma [2], [3]; romidepsin (

• lrrk2 br Conclusion The addition of cellulose to

  2022-06-02

  

  Conclusion The addition of lrrk2 to natural substrate increases the number of H-bonds which indicates an increase in the stability of the docking systems. The investigated compounds are more stable than natural substrate in docking systems, where the natural substrate has two H-bonds while the in

• On the basis of the structure of the Rab ACAP

  2022-06-02

  

  On the basis of the structure of the Rab35/ACAP2 complex, the authors identified Thr76 in switch II of Rab35 as one key specificity determinant (Lin et al., 2019). The crystal structure shows that the hydroxyl group of Thr76 forms a aldehyde dehydrogenase with Asp756 in ACAP2, while the methyl grou

• br GSNOR regulates SA synthesis and SA

  2022-06-02

  

  GSNOR1 regulates SA synthesis and SA signalling The phenolic metabolite salicylic TUG-770 mg (SA) is a powerful immune activator in plants. Moreover, mutations that disable SA biosynthesis or transgenes that result in its depletion compromise both resistance (R) gene-mediated and basal resistanc

• br Conclusions Beta cell specific expression in human

  2022-06-02

  

  Conclusions Beta cell-specific expression in human islets of DGCR2, GBF1, GPR44 and SerpinB10 has not previously been described, although the proteins have partly been characterized in other contexts not related to beta Pyrimethamine or diabetes. DGCR2, GPR44 and SerpinB10 were negative in all o

• SW033291 br Discovery of GPR A The murine niacin receptor pr

  2022-06-02

  

  Discovery of GPR109A The murine niacin receptor, protein upregulated in macrophages by interferon-γ (PUMA-G), was identified as a G-protein-coupled receptor (GPCR) expressed in adipocytes and spleen [22], [23]. This finding suggested a role of this receptor in macrophage function [24]. In 2003, t

• We also observed a significantly higher SLC A

  2022-06-01

  

  We also observed a significantly higher SLC10A1 gene expression and NTCP protein level among metastatic individuals vs. donor livers. Na+/taurocholate co-transporting polypeptide (NTCP), which is expressed on the basolateral membrane of hepatocytes and is primarily responsible for the uptake of bile

• br Conflict of interest br

  2022-06-01

  

  Conflict of interest Funding Acknowledgements Introduction to SLC6 transporters The solute carrier (SLC) 6 family of membrane proteins perform the Na+-coupled symport of amino acids and amino TPEN derivatives into cells throughout the body. Disrupting neurotransmitter SLC6-mediated tran

• Recent data from an investigation

  2022-06-01

  

  Recent data from an investigation conducted with beta-cell cultures and animals suggest that FFAR1 gene Calcein acetoxymethyl ester is modulated by stimulation of peroxisome proliferator-activated receptor gamma (PPARG) [10]. Intriguingly, in 2001 we had demonstrated effects of the PPARG Pro12Ala s

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