• Binary panel models can be

  2018-10-30

  

  Binary panel models can be estimated by the random effects methods (RE), in which the specific effect of the individual α is treated as a random variable with distribution g (α/γ), in which γ denotes additional parameters. Frequently, this is a normal distribution. Thus, the α is eliminated by integ

• Dinardo et al applied nonparametric methods to

  2018-10-30

  

  Dinardo et al. (1996) applied nonparametric methods to measure the effects of institutions and labor market factors on the changes of income distribution in the U.S. in the period 1979–1988. They concluded that labor unions and supply/demand shocks are vital to explain the income inequality rise in

• br The classification of industrial

  2018-10-30

  

  The classification of industrial goods: fundamentals and methods The well known Pavitt taxonomy has its origins in the famous article (Pavitt, 1984) which proposes a modification in relation to the previous patterns of industrial goods classification, especially on what concerns the empirical stu

• My focus is not on

  2018-10-30

  

  My focus is not on the actual (endogenous) decrease in corruption generated by the separation of middlemen. This decrease may be computed, in expected terms, for different technologies and contractual arrangements – i.e., separation or pilocarpine hydrochloride manufacturer of regulators. For the pu

• br Author Contributions br Conflict

  2018-10-30

  

  Author Contributions Conflict of Interest Acknowledgments and Role of the Funding Source This work was supported in part by the Chinese National Key Basic Research Project 973 Grant 2013CB966800, the Mega-projects of Science Research for the 12th Five-Year Plan (2013ZX09303302), the State K

• We describe here a mechanism that regulates the

  2018-10-30

  

  We describe here a mechanism that regulates the antioxidant response in order Tasquinimod performing OXPHOS in the absence of ROS increase. Mitochondria are the first source of ROS, although it is also the main organelle that assures their removal. ERK5 is essential for OXPHOS in leukemic cells (Ch

• Ten years ago Shinya Yamanaka and

  2018-10-30

  

  Ten years ago Shinya Yamanaka and colleagues from Kyoto University (Japan) described the creation of induced pluripotent stem MK0752 cost (iPSCs), first from mice, then humans a year later. The ability to ‘reprogram’ mature cells into iPSCs by introducing genes that encode specific transcription fa

• br Methods br Results VIS is an engineered human IgG

  2018-10-30

  

  Methods Results VIS410 is an engineered human IgG1 antibody that targets a unique, conserved conformational epitope on the stem of Influenza A virus HA protein (Tharakaraman et al., 2015). Previous studies have identified that VIS410 has broad reactivity against both group 1 and group 2 influe

• Adrucil A secondary outcome of interest was the arrest to bi

  2018-10-30

  

  A secondary outcome of interest was the arrest to birth interval. Out of 34 babies for whom the information is known, 4 newborns (11.8%) were delivered within 5min or less, 12 (35.3%) delivered from 5 to 11min, 8 (23.5%) delivered from 11 to 21min, and 10 (29.4%) delivered more than 21min after the

• br Size Stability and Toxicity A substantial number

  2018-10-30

  

  Size, Stability, and Toxicity A substantial number of investigations aiming to unravel the mechanism of the disease have accepted an intermediate structure of aggregated Aβ which is formed earlier than plaques and has been linked to the pathogenesis (Kayed and Lasagna-Reeves, 2013; Klein, 2013; H

• Hence nanobodies are very convenient tools for delivering to

  2018-10-30

  

  Hence, nanobodies are very convenient tools for delivering toxic cargos to cancer cells and are well-suited for chemical conjugation onto different nanoparticle formats. Moreover, they can boost the therapeutic effect when bearing intrinsic antagonistic activity. However, in vitro and in vivo data a

• Cities across Europe are already experiencing

  2018-10-30

  

  Cities across Europe are already experiencing an increase in ZIKV importations via travellers from the Americas (Maria et al., 2016; Zammarchi et al., 2015). Two recent studies assessed the risk of transmission of ZIKV in Europe reaching contrasting conclusions (Guzzetta et al., 2016; WHO, 2016). On

• br Materials and Methods br Results

  2018-10-30

  

  Materials and Methods Results Discussion There is increasing emphasis towards our understanding how PTH1R signaling is regulated, thus mediating PTH\'s dual functions: anabolic and catabolic responses. Here we provide several lines of evidence for VPS35, a major component of retromer, in re

• Despite the unprecedented progress of Zika research studies

  2018-10-29

  

  Despite the unprecedented progress of Zika research, studies of pathology related to ZIKV infection have been limited in humans, mainly due to the fact that about 80% of the infected individuals are asymptomatic, and for those who are symptomatic, most patients only exhibit mild diseases that do not

• br Experimental design materials and methods

  2018-10-29

  

  Experimental design, materials and methods Conflicts of interest Acknowledgments This work was supported by grants from Proyecto del Ministerio de Economía y Competitividad (SAF2013-47556-R, co-financed with FEDER funds), and the Fondo de Investigaciones Sanitarias (ISCIII-RETIC RD12/0018/0

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