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Indirect information on the developmental trajectory of the
2018-11-09

Indirect information on the developmental trajectory of the BRS comes from resting state functional magnetic resonance imaging (fMRI) studies. The sensorimotor control network is already topologically adult-like by the age of two while higher-order networks including the fronto-parietal network are
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Additional applications for organ on a
2018-11-09

Additional applications for organ-on-a-chip devices are expansive, including the assessment of environmental toxin (National Academies, 2014), modeling of disease progression and treatment (Bhatia and Ingber, 2014; Huh et al., 2012), the advancement of personalized medicine through the improvement o
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In the study by Wang et
2018-11-09

In the study by Wang et al., siRNA knockdown of renalase in the kidney abolished the RPC effect. This would at first glance appear attributable to decreased intracellular renalase, as this is where the siRNA works, but it is also possible that siRNA knockdown significantly decreased extracellular re
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Interestingly SR had an anabolic
2018-11-09

Interestingly, SR10171 had an anabolic effect on the appendicular but not the axial skeleton, whereas rosiglitazone had a negative effect in both skeletal sites. There are several possible explanations for this divergence. Firstly, osteocytes were shown to be a major anabolic target of SR10171. Thes
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voltage gated sodium channel During recall responses memory
2018-11-09

During recall responses, memory B cells can differentiate into antibody-secreting plasmablasts and plasma cells, re-initiate germinal centers for affinity maturation towards the new pathogen, and undergo self-renewing divisions. Distinct subsets of human memory B cells prefer one of these fates vs.
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Treating Age related Macular Degeneration Using Human
2018-11-09

Treating Age-related Macular Degeneration Using Human iPS Cells Age-related macular degeneration (AMD) is a medical condition of the eye that results in blurred vision and/or a loss of central vision. The wet form of AMD – caused by abnormal blood vessel growth – is often treated using anti-VEGF me
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In mortality YLD and all datasets only aggregated data
2018-11-09

In 2004 mortality, 2005 YLD and all 2013 datasets, only aggregated data was available for diarrhoea and enteric infectious disease and lower respiratory tract infections. For Salmonella, Escherichia coli, Shigellosis, Vibrio cholerae, Campylobacter, influenza and pneumonia, proportional estimates we
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Gametocyte carriage has been an efficacy end point
2018-11-09

Gametocyte carriage has been an efficacy end point in antimalarial drug studies but it is crucial to realise that gametocytaemia is a weak surrogate marker of mosquito infectivity. Gametocyte density has been shown to correlate with mosquito infectivity in untreated individuals in a non-linear relat
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One of the more critical contextual influences at
2018-11-09

One of the more critical contextual influences at hand is the availability and prevalence of substances of abuse, increasing the likelihood that individuals will select substance use as a risk behavior of choice. For example, in the United States, by age 18, 75.6% of adolescents have used alcohol, 4
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br Conflict of interest br
2018-11-09

Conflict of interest Acknowledgment Introduction Recently much effort has been spent in the area of microarrays to bring this technology into non-research markets [6,25]. One of the drivers for technology is the demand for point-of-care diagnostics (POC) [18]. Several attempts have been mad
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Since this kind of devices is based on the electrical
2018-11-09

Since this kind of devices is based on the electrical response of functionalized carbon nanotubes to antibody–antigen binding, they can be easily turned to detect other proteins by functionalizing CNTs with appropriate antibodies. Numerous studies revealed that proteins can interact in a non-specif
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br Numerical approach In order
2018-11-09

Numerical approach In order to perform our analysis in a realistic case we have considered the problem of the separation of the circulating tumor urat1 inhibitor (in particular MDA — MB 231 triple negative breast cells) from lymphocytes (LYM). The calculation of the f as a function of the frequen
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El reto de la reconfiguraci
2018-11-09

El reto de la reconfiguración escalar para incorporar al suroeste de México al crecimiento económico en el marco del ttp, pone de relieve el reciente proyecto de impulso CB-5083 las Zonas Económicas Especiales en esa región del país, el cual contempla el establecimiento de tres zee: en los municipio
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In the present study we
2018-11-09

In the present study we have focused our attention on the inflammatory cytokine interleukin 6 (IL6), based on the evidence that it is highly expressed in DMD patients and in mdx mouse model and it also plays a major role in inducing the transition from an acute neutrophilic infiltrate to a chronic t
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br Sickle Cell Disease SCD is
2018-11-09

Sickle Cell Disease (SCD) is one of the most common severe inherited disorders. Approximately 300,000 SCD babies are born yearly, mostly in Africa, the USA and the Caribbean, but also in Northern Europe (). In the UK, SCD patients number around 12–15,000 individuals () making it D609 cost a disea
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