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br Conflicts of interest br Introduction When it
2024-06-17
Conflicts of interest Introduction When it comes to risk taking, surgeons and anesthesiologists show greater risk taking than other physicians. Surgical procedures carry several risks of which infection is one. Surgical site infections (SSI) are the most common hospital acquired infection and
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br Serine glycine and one
2024-06-14
Serine/glycine and one-carbon metabolism Altered serine metabolism in tumors was noted nearly half a century ago, and elevated flux through the de novo serine synthesis pathway (SSP) is a common phenomenon in cancer GSK1324726A [43]. The SSP branches from glycolysis at the point of 3-phosphoglyce
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In the QFP rs T allele showed a significant correlation
2024-06-14
In the QFP, rs2269657-T allele showed a significant correlation with reduced plaque density in frontal cortices (Table 2), strengthening the association with amyloid pathology. The same ambroxol hydrochloride receptor region was shown to exhibit a statistically significant reduction of SREBF2 mRNA
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It thus appeared reasonable that AR needed to be inhibited
2024-06-14
It thus appeared reasonable that AR needed to be inhibited and great experimental efforts began which are still on-going [6]. Indeed, hundreds of ARIs have been characterized but no significant drug development has followed. The case of Sorbinil, which did not pass clinical trials is emblematic [7]
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AdipoR and AdipoR have been reported
2024-06-14
AdipoR1 and AdipoR2 have been reported to be present in almost all type of tissues and low stock aee levels have been observed in white adipose tissue (Inukai et al., 2005). These receptors have been observed to become deregulated with the onset of obesity, resulting in a reduced level of APN expre
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AdipoR and AdipoR have been reported
2024-06-14
AdipoR1 and AdipoR2 have been reported to be present in almost all type of tissues and low Palosuran levels have been observed in white adipose tissue (Inukai et al., 2005). These receptors have been observed to become deregulated with the onset of obesity, resulting in a reduced level of APN expres
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Children with ADA SCID commonly suffer from a variety of
2024-06-14
Children with ADA-SCID commonly suffer from a variety of opportunistic infections, including viral, fungal, and mycobacterial infections. Due to defects in H-Lys(Ac)-OH.HCl synthesis and IG production, they are also susceptible to infection with encapsulated bacteria such as Haemophilus influenzae
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As a continuation of our search for
2024-06-14
As a continuation of our search for a selective AChE radioligand bearing a meta-F substituted N-benzyl moiety, we designed and synthesized a novel meta-F-CP-118,954 analog along with a meta-18F-labeled form via diaryliodonium salt-based precursor (Fig. 1). For comparative purposes, we incorporate th
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A contribution of V ATPase subunits specifically to
2024-06-14
A contribution of V-ATPase subunits specifically to phagosome-lysosome fusion was uncovered by Peri and Nüsslein-Volhard who described that depletion of the VO subunit a1 in zebrafish interferes with phagosome maturation in microglial Neurotensin (Peri and Nusslein-Volhard, 2008). However, loss of t
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br Introduction Lung cancer is the leading cause of cancer
2024-06-14
Introduction Lung cancer is the leading cause of cancer death worldwide and is one of the most refractory of solid tumors along with pancreatic cancer. Since 1975 there have been notable improvements in the 5-year survival rate of patients with lung cancer [1]. This improvement in survival is tho
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Aromatization of the pyrrole ring after anion capturing
2024-06-14
Aromatization of the pyrrole ring after anion capturing, using acceptor atoms with electron deficiency (B & Be), and substitution of strong electron withdrawing groups such as CN were three strategies used to design a new class of anion receptors. Comparison of the anion affinities of these anion re
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Although the LB domains of mGlu
2024-06-14
Although the LB2 domains of mGlu receptors have not been shown to form an extensive interface during activation, they do draw closer to each other, as demonstrated in crystal structures (Kunishima et al., 2000, Muto et al., 2007, Tsuchiya et al., 2002) and by FRET analysis (Doumazane et al., 2013, V
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Serum concentrations of acute phase proteins APP and of anti
2024-06-13
Serum concentrations of acute phase proteins (APP) and of antioxidants have proved to be clinically useful biomarkers of pyometra in different species, including bitches, cows and mares [[11], [12], [13], [14], [15]]. Acute phase proteins are being increasingly used in both human and veterinary medi
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We report here the case of a
2024-06-13
We report here the case of a patient with probable genetic prion disease with a Creutzfeldt-Jakob disease-like phenotype associated with a rare PRNP E196K mutation who initially exhibited atypical clinical manifestations principally characterized by behavioral abnormalities. Case report An 80-ye
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br Results and discussion The soil fungus PSU RSPG BCC
2024-06-13
Results and discussion The soil fungus PSU-RSPG37 (BCC56870) was isolated from soil samples collected from Rajjaprabha Dam, Suratthani Province, Thailand. The fungus was deposited at BIOTEC Culture Collection, National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Pa
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